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Look at the earlier thread about 7.5.3 horde problems. I followed the advice there (including the 5.0 loader), restarted the plesk services and it cured the horde problem (and problems with other php-dependent websites).
I'm not sure why (or if?) horde requires ioncube. Somebody else may have more information on that.
Actually, until about this time yesterday, I thought an ioncube was something used to sweeten inter-galactic coffee
I tried this in several steps, but things started working after I installed the updated ioncube loaders and then pointed the ini files to the 5.0 loaders.
The ioncube loaders were referenced in 2 ini files and in 2 locations on my server. I updated both ini files and placed the updated loaders in both locations.
I restarted plesk services using psa stopall then psa start.