I had Sitebuilder installed, ran the "sitebuilder update" in the Plesk Update page, and immediately Sitebuilder was down and all MySQL and PHP sites failed. Be CAREFUL when you run the updates, especially on weekends when the support goes from 6 to 12 hour response. Appears it may be a conflict with ioncube but I won't know anything until Plesk Support sorts it all out. In the mean time Sitebuilder is down along with about 30 other sites. Just a word of caution to others..... Be careful!