I solve it :)
just add rewrite rule and handlers in web.config like this :
<handlers>
<add name="iisnode" path="server.js" verb="*" modules="iisnode" />
</handlers>
<rewrite>
<rules>
<rule name="myapp">
<match url="/*" />
<action...
I upload and extract this GitHub - plesk/node-express: A simple Express-based app to test Node.js support. project on /httpdocs folder and change Application
Startup File to server.js and after browsing the domain like this : http://www.mydomain.com and see
Express welcome message
but when...