Latest version of Sitebuilder supports following SuSe OSes:
SuSE 9.3(x86, x86_64), 10.0(x86, x86_64), 10.1(x86, x86_64), 10.2(x86, x86_64), 10.3(x86, x86_64)
http://www.parallels.com/products/plesk/sitebuilder/reqs/
So it is not guaranteed that it (4.3 or 4.5 versions) will work properly...