I am fairly new to plesk, so i might regret a post that will prove that perhaps i just don't get it, but setting up asp.net in plesk is not the simplest issue. The asp.net tester page in the default setup cannot connect to my test msde db at all, errors abound. To get my working asp.net application to work at the ip controlled by plesk i had to do the followiing, each of which was not independently tested, just a cumulative set of steps needed to try and meet a deadline. â€¢ i enabled debugging as a starting point. â€¢ working in IIS6, we should only need to have NETWORK SERVICE as the permission'd user, or at least in my experience. I had to add full perm's to vhosts, and to the httpdocs folders for both this user and for ASPNET which is a IIS5 thing. â€¢ i also needed to add both user with read|write|list to the windows temp folder. â€¢ then finally i added IIS_WPG, and my app worked. I likely took other steps, but don't remember now. These permissions are at the root of countless posts, from folks looking for help. Perhaps this might be considered for the next plesk update? thanks, and hopefully this helps others, drew..