• The BIND DNS server has already been deprecated and removed from Plesk for Windows.
    If a Plesk for Windows server is still using BIND, the upgrade to Plesk Obsidian 18.0.70 will be unavailable until the administrator switches the DNS server to Microsoft DNS. We strongly recommend transitioning to Microsoft DNS within the next 6 weeks, before the Plesk 18.0.70 release.
  • The Horde component is removed from Plesk Installer. We recommend switching to another webmail software supported in Plesk.

Mail Enable 6

I know what is supported, but sometimes new versions just work ;-) I wanted to upgrade from 3 to 5 and now 6 is out I can not / don't want to upgrade to 5.
 
You can upgrade it only on your risk. We can't guarantee that unsupported third-party software will work correctly in Plesk environment.
 
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