It won't support it immediately (release dates are too much close) and will require an update for 10.4will 10.4 support openSuSE 12.1 which will be released in early mid of november?
Is there an ETA for an Patch for openSuSE 12.1, i'd like to upgrade but i can't even load a new version of Plesk 10.4 at the moment, but i can upgrade in my old panel.