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If you are still using CentOS 7.9, it's time to convert to Alma 8 with the free centos2alma tool by Plesk or Plesk Migrator. Please let us know your experiences or concerns in this thread: CentOS2Alma discussion
Plesk 12.0.18
Postfix+Courier-IMAP
Mail is sent from the Roundcube perfectly. When sending a response, it gives an error
554 5.7.1 : Relay access denied
Help solve the problem
If you still experience issues/errors/problems, try to include depending configuration files and don't forget to include MORE from your mail - logs ( serverwide AND from roundcube ) for further investigations.