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Webmail Mailenable error 500

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Navigate within IIS to where the "Mewebmail" application resides under and check the path. It should not be like \Plesk\.\Mail Servers\Mail Enable\Bin\NETWebMail for example.
 
Can you clarify? Because i don't see Mewebmail on Applications Pools !!!! Is there a way to fix this installation?
 
This is real error:


HTTP Error 500.0 - Internal Server Error
Calling LoadLibraryEx on ISAPI filter "C:\Windows\Microsoft.NET\Framework\v4.0.30319\\aspnet_filter.dll" failed
 
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