It is NOT recommended to turn off the Web Application Firewall.
As an alternative, one could use the (less restrictive) ruleset from Comodo.
As another alternative, one could tweak the OWASP rules - not the rules themselves, but add some exclusions, as @Maarten. pointed out.
However, in some cases, OWASP CRS has exclusion sets for specific programs - for instance, there is an exclusion set for WordPress.
I would suggest that you start with Comodo ruleset, keep track of the modsec_audit.log file and - if necessary - activate the more strict OWASP ruleset.