emails go to spam

[blackmetal]

Hello,
any domain from my server when send email to gmail (only gmail, or some times yahoo) from horde it goes spam box immedieatly i check my server configuration, check all of my server ip in mxtoolbox.com for rbl's(they are not blacklisted) and etc but i could not check what is the issue for, but when i send email from a asp.net email form it goes to inbox in gmail! but from webmail it goes to spam box! how can i solve this issue?
i am using w2k8 r2 64bit with mailenable standard and horde ,

THanks,