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Issue Nginx huge problems! Please Help

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Basic Pleskian
Hi, I have a platform that I administrate on my Linux server (with Plesk obv).
In the last 4 hours, the domain that is on this server, was unreachable 2 times.
And the logs of the errors are this:


127188#0: *102251 connect() failed (111: Connection refused) while connecting to upstream
Please Help!
 
Hi @TravisB , I have already White-listed the Ip of my office, the Ip of the server and the all of right connections that my server has.
 
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