• The APS Catalog has been deprecated and removed from all Plesk Obsidian versions.
    Applications already installed from the APS Catalog will continue working. However, Plesk will no longer provide support for APS applications.
  • Please be aware: with the Plesk Obsidian 18.0.78 release, the support for the ngx_pagespeed.so module will be deprecated and removed from the sw-nginx package.

Question Security hardening and backups

Yes it will, the hardening is usually better done after the sites completed and requires little or no editing, the restrictions put on certain directories will indeed break Duplicator or any other similar backup/cloning tool. I'd disable them while you use Duplicator then re-enable them after.
 
Actually it depends on Duplicator plugin implementation. I don't think these security restrictions should cause any issues, but who knows. The only way to know is to install the plugin and actually try backup/restore/move.
 
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