I have a number of domains on my plesk server all with the mail accounts disabled. This is because I use another mail server on another server. I am using CDO in my asp scripts to send webbased emails from asp pages and using 127.0.0.1 to relay through mailenable. I do it this way as I am unable to start the SMTP server in IIS (I/O device error). This works through mailenable except for domains that are local on the server, ie domains that exist already on the server, apart from one domain. All settings are equal and I don't understand why one domain works! This is the error message I typically get from all the other domains: ME-E0105: Local Delivery: Failure - Domain for ([SMTP:email@example.com]) has been disabled Any ideas?