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On Plesk for Linux mod_status is disabled on upgrades to improve Apache security. This is a one-time operation that occurs during an upgrade. You can manually enable mod_status later if needed.
I only had a problem on one server where SP1 botched the security permissions for all NON Windows services, so all of PSAs services would fail to start. I haven't seen or heard this happen anywhere else (figures). I don't blame this on PSA though as 7.5.x was originally built to take advantage of SP1. As long as you properly back everything up before changing anything, your ok.
MailEnable Professional doesn't get along with DEP in SP1 so if you have an Opteron based server you'll need to turn that off or none of the ME services will start.