Problem about Sitebuilder with Zend Optimizer and ioncube loader

[anto g]

Hi,
I have a problem with Sitebuilder.
I have a server with ioncube and zend optimizer, but when i try to connect to Sitebuilder, i receive the following error message:

Internal Server Error
The server encountered an internal error or misconfiguration and was unable to complete your request.

Is it possible to install Sitebuilder 4.0 / 4.5 on a server with Zend Optimizer and IonCube Loader?
If yes, how do i have to setup these modules?

Thank you in advance.

Anto