Why on earth would you want the overhead of doing that? If you were to do this, do it on a dedicated machine and setup 5 startup scripts for mysqld to listen on 5 different ports, each with their own data directory. Like I said, sounds like a goofy and not sure why you would want to do this. Setup a dedicated database machine or machines and run mysql or a mysql cluster and map the remote mysql server through the PSA control panel. Thats how I do it, and I have 0 problems with many high traffic sites many using large databases.